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Daily Stressors

Life’s daily stressors are inevitable, but prioritizing your inner health—mind, body, and soul—can be transformative. Antioxidants are essential for protecting against free radicals, which multiply under modern-day stress, weakening our immune system. With proper hydration, vitamins, and minerals, your body gains the support it needs to reduce free radicals and function at its best. IV hydration offers powerful benefits, like boosting energy, strengthening immunity, and enhancing skin texture, while aiding in detoxification. Investing in your health by nurturing your body from within will bring lasting benefits, helping you feel and look revitalized for the long term.

Vitamin C Deficiency

Vitamin C deficiency is common among cancer patients, with lower serum and salivary levels linked to oral cancers and potentially malignant disorders. While oral vitamin C supplementation has not shown significant therapeutic benefit, intravenous (IV) administration offers promising results, particularly in advanced cancers. IV vitamin C achieves plasma concentrations far higher than oral dosing, enabling it to potentially generate oxidative stress that selectively targets cancer cells due to their lower catalase levels. High-dose IV vitamin C has demonstrated antitumor and chemo-sensitizing properties, showing efficacy in reducing tumor size and alleviating treatment-related side effects, including fatigue, nausea, and pain. This adjunct therapy has enhanced quality of life and reduced adverse effects in patients undergoing chemotherapy, with manageable side effects such as mild nausea. However, controlled studies are still required to confirm its impact on survival outcomes. Overall, IV vitamin C appears to provide safe, supportive benefits for patients with advanced cancer.

References

  1. Haworth WN, Hirst EL. Synthesis of ascorbic acid. J Soc Chem Ind (Lond). 1933;52:645–647.
  2. Nishikimi M, Fukuyama R, Minoshima S, Shimizu N, Yagi K. Cloning and chromosomal mapping of the human nonfunctional gene for L-gulono-gamma-lactone oxidase, the enzyme for L-ascorbic acid biosynthesis missing in man. J Biol Chem. 1994;269:13685–13688.
  3. Dunitz JD. Linus Carl Pauling. 28 February 1901–19 August 1994. Biographical Memoirs of Fellows of the Royal Society. 1996;42:316–318. doi:10.1098/rsbm.1996.0024.
  4. Stevenson NR, Brush MK. Existence and characteristic of Na+-dependent active transport of ascorbic acid in guinea pigs. Am J Clin Nutr. 1969;22:318. doi:10.1093/ajcn/22.3.318.
  5. Malo C, Wilson JX. Glucose modulates vitamin C transport in adult human small intestinal brush border membrane vesicles. J Nutr. 2000;130:63–69. doi:10.1093/jn/130.1.63.
  6. Takanga H, Mackenzie B, Hediger MA. Sodium-dependent ascorbic acid transporter family SLC23. Pflugers Arch. 2004;447:677–682. doi:10.1007/s00424-003-1104-1.
  7. Stewart JS, Booth CC. Ascorbic acid absorption in malabsorption. Acta Gastroenterol Belg. 1964;27:567–568.

Vitamin B

These vitamins are crucial for energy production, nervous system function, and overall cellular health. They play a vital role in supporting brain function, boosting energy levels, and promoting the growth of red blood cells, while also helping to strengthen the body’s defenses against infections.

Zinc

Zinc is an essential trace mineral that strengthens the immune system, aiding in the fight against bacteria and viruses. It supports faster wound healing, regulates hormones to prevent hair loss, and may help lower blood sugar and cholesterol in diabetes. Zinc also reduces inflammation and minimizes acne-related redness.

Glycine

Glycine is a non-essential amino acid, but it plays a surprisingly important role in multiple systems:

  1. Protein building block  
  2. Neurotransmitter in the brain 
  3. Involved in making glutathione
Sleep improvement
  1. May help you fall asleep faster
  2. Can improve sleep quality and next-day alertness
  3. Works by calming the nervous system and lowering body temperature

Collagen & skin support

  1. Glycine makes up about ⅓ of collagen
  2. Important for:
    • Skin
    • Joints
    • Connective tissue

Nervous system calming effect

Glycine acts as an inhibitory neurotransmitter:

  1. Helps reduce overactive brain signals
  2. Supports relaxation and mental calm

Metabolic health

Some research suggests glycine may:

  1. Improve insulin sensitivity
  2. Support blood sugar control

Muscle performance

  1. May support recovery and reduce fatigue
  2. Not a major muscle-building supplement

Alpha-lipoic acid (ALA)

Alpha-lipoic acid (ALA) has garnered interest for its potential to aid in the management of multiple health conditions due to its antioxidant, anti-inflammatory, and hypoglycemic properties. Notably, in type-2 diabetes, ALA has been shown to enhance insulin sensitivity, improve glucose effectiveness, and support cardiac health. Intravenous ALA, in particular, offers superior benefits for improving glucose metabolism. ALA has also shown mixed but promising results in alleviating symptoms of burning mouth syndrome (BMS), with some studies reporting significant symptom relief. In conditions involving chronic inflammation and oxidative stress, such as fibromyalgia and chronic fatigue syndrome, ALA’s antioxidative properties, coupled with its role in mitochondrial function, are believed to alleviate symptoms. Additionally, pre-clinical cancer research indicates ALA’s potential to inhibit cancer cell proliferation by promoting cellular apoptosis and reducing oxidative stress. In cardiovascular health, ALA may reduce atherosclerosis progression by decreasing oxidative stress, lowering cholesterol levels, and supporting vascular function. Although primarily supported by experimental data, ALA’s safety profile and multi-targeted benefits highlight it as a promising supplement in managing complex conditions related to oxidative stress and inflammation.

References

  1. Paolisso G, D’Amore A, Volpe C, Balbi V, Saccomanno F, Galzerano D, Giugliano D, Varricchio M, D’Onofrio F. Evidence for a relationship between oxidative stress and insulin action in non-insulin-dependent (type II) diabetic patients. Metabolism. 1994;43:1426–1429.

  2. Rochette L, Ghibu S, Muresan A, Vergely C. Alpha-lipoic acid: molecular mechanisms and therapeutic potential in diabetes. Can J Physiol Pharmacol. 2015;93(12):1021–1027.

  3. Akbari M, Ostadmohammadi V, Tabrizi R, et al. The effects of alpha-lipoic acid supplementation on inflammatory markers among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab. 2018;15(1):1–10.

  4. Konrad T, Vicini P, Kusterer K, Hoflich A, Assadkhani A, Bohles HJ, Sewell A, Tritschler HJ, Cobelli C, Usadel KH. Alpha-lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care. 1999;22:280–287.

  5. Ziegler D, Gries FA. Alpha-lipoic acid in the treatment of diabetic peripheral and cardiac autonomic neuropathy. Diabetes. 1997;46(Suppl 2):S62–S66.

  6. Jacob S, Henriksen EJ, Schiemann AL, Simon I, Clancy DE, Tritschler HJ, Jung WI, Augustin HJ, Dietze GJ. Enhancement of glucose disposal in patients with type 2 diabetes by alpha-lipoic acid. Arzneimittelforschung. 1995;45:872–874.

  7. Jacob S, Henriksen EJ, Tritschler HJ, Augustin HJ, Dietze GJ. Improvement of insulin-stimulated glucose disposal in type 2 diabetes after repeated parenteral administration of thioctic acid. Exp Clin Endocrinol Diabetes. 1996;104:284–288.

  8. Jacob S, Ruus P, Hermann R, Tritschler HJ, Maerker E, Renn W, Augustin HJ, Dietze GJ, Rett K. Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type 2 diabetes mellitus: a placebo-controlled pilot trial. Free Radic Biol Med. 1999;27:309–314.

  9. Evans JL, Goldfine ID. Alpha-lipoic acid: a multifunctional antioxidant that improves insulin sensitivity in patients with type 2 diabetes. Diabetes Technol Ther. 2000;2(3):401–413.

Asthma & Magnesium

Bronchial asthma, a chronic inflammatory condition affecting 334 million people globally, is increasingly linked to magnesium deficiency, which contributes to inflammation and worsens asthma severity. Studies show that low serum magnesium levels correlate with poor asthma control, and asthmatics often have significantly lower magnesium levels than healthy individuals. While oral magnesium offers limited improvement and nebulized magnesium shows variable benefits, intravenous magnesium has demonstrated consistent efficacy, particularly during severe asthma attacks, reducing hospitalization rates and improving respiratory function. This treatment approach has a favorable safety profile, though additional research is needed to explore its preventive potential in asthma management.

Refrences

  1. Shahi A, Aslani S, Ataollahi M, Mahmoudi M. The role of magnesium in different inflammatory diseases. Inflammopharmacology. 2019;27(4):649–661.

  2. Revyakina VA, Korotkova TN, Kuvshinova ED, Larkova IA, Alexandrova NM. [Magnesium and vitamin B2 status of children with bronchial asthma and obesity.] Vopr Pitan. 2019;88(3):78–83.

  3. Daliparty VM, Manu MK, Mohapatra AK. Serum magnesium levels and its correlation with level of control in patients with asthma: A hospital-based, cross-sectional, prospective study. Lung India. 2018;35(5):407–410.

  4. Shaikh MN, Malapati BR, Gokani R, Patel B, Chatriwala M. Serum magnesium and vitamin D levels as indicators of asthma severity. Pulm Med. 2016;2016:1643717.

  5. Mao S, Wu L, Shi W. Association between trace elements levels and asthma susceptibility. Respir Med. 2018;145:110–119.

  6. Kılıc H, Kanbay A, Karalezlı A, Babaoglu E, Hasanoglu HC, Erel O, Ates C. The relationship between hypomagnesemia and pulmonary function tests in patients with chronic asthma. Med Princ Pract. 2018;27(2):139–144.

  7. Sandhu MS, Casale TB. The role of vitamin D in asthma. Ann Allergy Asthma Immunol. 2010;105(3):191–199; quiz 200–202, 217.

  8. Abuabat F, AlAlwan A, Masuadi E, Murad MH, Jahdali HA, Ferwana MS. The role of oral magnesium supplements for the management of stable bronchial asthma: A systematic review and meta-analysis. NPJ Prim Care Respir Med. 2019;29(1):4.

  9. Chande VT, Skoner DP. A trial of nebulized magnesium sulfate to reverse bronchospasm in asthmatic patients. Ann Emerg Med. 1992;21(9):1111–1115.

  10. Zandsteeg AM, Hirmann P, Pasma HR, Yska JP, ten Brinke A. Effect of MgSO₄ on FEV₁ in stable severe asthma patients with chronic airflow limitation. Magnes Res. 2009;22(4):256–261.

  11. Hossein S, Pegah A, Davood F, Said A, Babak M, Mani M, Mahdi R, Peyman H. The effect of nebulized magnesium sulfate in the treatment of moderate to severe asthma attacks: A randomized clinical trial. Am J Emerg Med. 2016;34(5):883–886.

  12. Knightly R, Milan SJ, Hughes R, Knopp-Sihota JA, Rowe BH, Normansell R, Powell C. Inhaled magnesium sulfate in the treatment of acute asthma. Cochrane Database Syst Rev. 2017;11(CD003898). DOI: 10.1002/14651858.CD003898.pub6.

  13. Tiffany BR, Berk WA, Todd IK, White SR. Magnesium bolus or infusion fails to improve expiratory flow in acute asthma exacerbations. Chest. 1993;104:831–834.

  14. Green SM, Rothrock SG. Intravenous magnesium for acute asthma: Failure to decrease emergency treatment duration or need for hospitalization. Ann Emerg Med. 1992;21:260–265.

  15. Rowe BH, Bretzlaff JA, Bourdon C, Bota GW, Camargo CA Jr. Intravenous magnesium sulfate treatment for acute asthma in the emergency department: A systematic review of the literature. Ann Emerg Med. 2000;36(3):181–190.

  16. Irazuzta JE, Chiriboga N. [Magnesium sulfate infusion for acute asthma in the emergency department – Infusão de sulfato de magnésio para asma aguda no serviço de emergência.] Jornal de Pediatria. 2017;93(1):19–25.

  17. Stojak BJ, Halajian E, Guthmann RA, Nashelsky J. Intravenous magnesium sulfate for acute asthma exacerbations. Am Fam Physician. 2019;99(2):127–128.

  18. Schenk P, Vonbank K, Schnack B, Haber P, Lehr S, Smetana R. Intravenous magnesium sulfate for bronchial hyperreactivity: A randomized, controlled, double-blind study. Clin Pharmacol Ther. 2001;69(5):365–371.

  19. Liu X, Yu T, Rower JE, Campbell SC, Sherwin CM, Johnson MD. Optimizing the use of intravenous magnesium sulfate for acute asthma treatment in children. Pediatr Pulmonol. 2016;51(12):1414–1421.

  20. Rowe BH, Camargo CA Jr. The role of magnesium sulfate in the acute and chronic management of asthma. Curr Opin Pulm Med. 2008;14(1):70–76.

  21. Ohn M, Jacobe S. Magnesium should be given to all children presenting to hospital with acute severe asthma. Paediatr Respir Rev. 2014;15(4):319–321.

  22. Gaby AR. Intravenous nutrient therapy: The “Myers’ cocktail.” Altern Med Rev. 2002;7(5):389–403.

  23. Kokotajlo S, Degnan L, Meyers R, Siu A, Robinson C. Use of intravenous magnesium sulfate for the treatment of an acute asthma exacerbation in pediatric patients. J Pediatr Pharmacol Ther. 2014;19(2):91–97.

B12 & Neuropathy

Vitamin B12 deficiency, often resulting from poor dietary intake, gastrointestinal issues, or long-term metformin use in diabetics, can lead to neurological complications like peripheral neuropathy. This neuropathy is thought to stem from disruptions in central nervous system methylation, specifically due to inhibited B12-dependent methionine synthase. Studies show that while oral B12 supplementation offers limited relief, combining intravenous and oral B12 is significantly more effective, enhancing nerve function and reducing symptoms more rapidly. Furthermore, high-dose intravenous B12 appears safe and promising for progressive neuropathies, though additional research is needed to fully understand its therapeutic potential across various neurological conditions.

Refrences

  1. Pavlov CS, Damulin IV, Shulpekova YO, Andreev EA. Neurological disorders in vitamin B12 deficiency. Ter Arkh. 2019;91(4):122–129.

  2. Weir DG, Scott JM. The biochemical basis of the neuropathy in cobalamin deficiency. Baillieres Clin Haematol. 1995;8(3):479–497.

  3. McCombe PA, McLeod JG. The peripheral neuropathy of vitamin B12 deficiency. J Neurol Sci. 1984;66(1):117–126.

  4. Saperstein DS, Barohn RJ. Peripheral neuropathy due to cobalamin deficiency. Curr Treat Options Neurol. 2002;4(3):197–201.

  5. Head KA. Peripheral neuropathy: pathogenic mechanisms and alternative therapies. Altern Med Rev. 2006;11(4):294–329.

  6. Alvarez M, Rincon O, Saavedra G, Moreno SM. Vitamin B12 deficiency and diabetic neuropathy in patients taking metformin: A cross-sectional study. Endocr Connect. 2019;8(12):1523–1530.

  7. Ahmed MA, Muntingh G, Rheeder P. Vitamin B12 deficiency in metformin-treated type 2 diabetes patients, prevalence and association with peripheral neuropathy. BMC Pharmacol Toxicol. 2016;17(1):44.

  8. Bell DS. Metformin-induced vitamin B12 deficiency presenting as a peripheral neuropathy. South Med J. 2010;103(3):265–267.

  9. Healton EB, Savage DG, Brust JC, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore). 1991;70(4):229–245.

  10. Saperstein DS, Barohn RJ. Peripheral neuropathy due to cobalamin deficiency. Curr Treat Options Neurol. 2002;4(3):197–201.

  11. Jayabalan B, Low LL. Vitamin B supplementation for diabetic peripheral neuropathy. Singapore Med J. 2016;57(2):55–59.

  12. Parry-Strong A, Langdana F, Haeusler S, Weatherall M, Krebs J. Sublingual vitamin B12 compared to intramuscular injection in patients with type 2 diabetes treated with metformin: A randomized trial. N Z Med J. 2016;129(1436):67–75.

  13. Sil A, Kumar H, Mondal RD, et al. A randomized, open-labeled study comparing the serum levels of cobalamin after three doses of 500 mcg vs. a single dose of 1500 mcg methylcobalamin in patients with peripheral neuropathy. Korean J Pain. 2018;31(3):183–190.

  14. Yamane K, Usui T, Yamamoto T, Tsukamoto T, Soma Y, Yoshimura N, et al. Clinical efficacy of intravenous plus oral mecobalamin in patients with peripheral neuropathy using vibration perception thresholds as an indicator of improvement. Curr Ther Res Clin Exp. 1995;56:656–670.

  15. Shibuya K, Misawa S, Nasu S, Sekiguchi Y, Beppu M, Iwai Y, Mitsuma S, Isose S, Arimura K, Kaji R, Kuwabara S. Safety and efficacy of intravenous ultra-high dose methylcobalamin treatment for peripheral neuropathy: A phase I/II open-label clinical trial. Intern Med. 2014;53(17):1927–1931.

  16. Kuwabara S, Nakazawa R, Azuma N, Suzuki M, Miyajima K, Fukutake T, Hattori T. Intravenous methylcobalamin treatment for uremic and diabetic neuropathy in chronic hemodialysis patients. Intern Med. 1999;38(6):472–475.

  17. Calderón-Ospina CA, Nava-Mesa MO. B vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin. CNS Neurosci Ther. 2019;25(4):304–313.

  18. Solomon LR. Vitamin B12-responsive neuropathies: A case series. Nutr Neurosci. 2016;19(4):162–168.

  19. Franques J, Chiche L, De Paula AM, Grapperon AM, Attarian S, Pouget J, Mathis S. Characteristics of patients with vitamin B12-responsive neuropathy: A case series with systematic repeated electrophysiological assessment. Neurol Res. 2019;41(6):569–576.

  20. Friedman BT, Chen BC, Latimer AJ, Valento MJ. Iatrogenic pediatric hydroxocobalamin overdose. Am J Emerg Med. 2019;37(7):1394.e1–1394.e2.

Aging

Glutathione, a powerful antioxidant crucial for cell survival and detoxification, is essential for protecting cells from oxidative damage. As we age, the body’s ability to synthesize glutathione declines, leading to increased oxidative stress, as seen in higher plasma markers of oxidant damage. Studies show that glutathione levels in individuals aged 60–79 are about 17% lower than in younger adults, raising susceptibility to age-related conditions such as cognitive impairment, cataracts, and immune deficiencies.
Research has linked higher glutathione levels with better physical and mental health in older adults, suggesting a connection between glutathione and longevity. Supplementing glutathione can help counter the natural decline, potentially reducing visible signs of aging like wrinkles and enhancing skin elasticity.

Skin

Glutathione has been explored as a treatment for hyperpigmentation conditions, including melasma and post-inflammatory hyperpigmentation, due to its potential to inhibit the enzyme tyrosinase and shift melanin production toward lighter pigments. While oral, topical, and intravenous glutathione applications have shown promising results in reducing melanin, there is limited controlled research confirming its effectiveness.

Oral glutathione, in capsule or lozenge form, has been associated with reduced melanin indices after 2-4 weeks of use, with no serious adverse effects reported. Topical applications of 2% oxidized glutathione lotion have shown improvements in skin smoothness and hydration and reductions in wrinkles and melanin on treated areas. However, in a study on intravenous glutathione, some participants experienced liver function abnormalities and anaphylaxis, potentially due to other product ingredients. Further well-controlled, long-term studies are needed to verify the safety and efficacy of intravenous glutathione for hyperpigmentation treatment.

Refrences

  1. MacDonald Baker S. The metaphor of oceanic disease. Integrative Med Clin J. 2008;7(1):40–45.

  2. Pizzorno J. The path ahead: measuring oxidative stress. Integrative Med Clin J. 2009;8(3):8–10.

  3. Pizzorno J. The path ahead: is mercury toxicity an epidemic? (Part II). Integrative Med Clin J. 2009;8(2):8–12.

Weight Loss MIC

Methionine, Inositol, and Choline (MIC) Injections
Methionine, Inositol, and Choline (MIC) injections are often marketed as “fat-burning” treatments intended to support weight loss when combined with a low-calorie diet and regular exercise. Evidence on the effectiveness and safety of MIC injections for weight loss is, however, limited and inconsistent. Some studies suggest that MIC injections may reduce body weight, body fat, BMI, and waist circumference in obese individuals, while other studies show no significant weight loss effects compared to placebo. The outcomes of MIC injections on weight loss may vary depending on the dosage, frequency, MIC formula type, and individual factors such as baseline weight and activity level.

Liver Support
MIC injections may also support liver health by impacting phosphatidylcholine (PC) synthesis, a key component for cell membranes, particularly in the liver. Choline deficiency can lead to fatty liver disease, where excess fat accumulates in liver cells, increasing risks of liver inflammation and related conditions. Supplementing MIC may help prevent or address fatty liver disease by restoring PC synthesis, enhancing lipid metabolism, and reducing oxidative stress in the liver. A meta-analysis involving 1,032 participants with fatty liver disease found that choline supplementation significantly lowered serum markers of liver injury, specifically ALT and AST levels, compared to placebo. However, the optimal dosage and duration of MIC supplementation for liver health are still uncertain and may vary with the severity of liver conditions.

NAD + Drip Therapy

Support healthy aging. Restore energy from within.

NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme found in every cell of the body. It plays a key role in cellular energy production, especially within the mitochondria—often referred to as the powerhouse of the cell.

In our younger years, NAD+ levels are naturally high, fueling energy, mental sharpness, and physical resilience. But as we age, NAD+ production declines significantly—by up to 40% by the age of 40. This reduction is closely tied to common signs of aging such as fatigue, brain fog, decreased mobility, and slower recovery.

NAD+ IV Therapy helps replenish these declining levels, supporting increased cellular energy, mental clarity, and overall vitality. It’s a slow-drip treatment that typically lasts between 2 to 3 hours, giving your body time to absorb and benefit from the infusion.

Administered in the comfort of our IV wellness clinic, NAD+ Therapy offers a rejuvenating experience designed to help you feel more energized, focused, and balanced.

Making you feel alive again

Health and wellness should be easy! Let our certified providers bring personalized IV therapy and weight loss services to your doorstep.

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